AustralieFrV1, Main, Exploration, bibRecord, 004766

Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions

Identifieur interne : 004766 ( Main/Exploration ); précédent : 004765; suivant : 004767

Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions

Auteurs : Athar Aziz [Royaume-Uni] ; E. Joanna Baxter [Royaume-Uni] ; Carol Edwards [Royaume-Uni] ; Clara Yujing Cheong [Singapour] ; Mitsuteru Ito [Royaume-Uni] ; Anthony Bench [Royaume-Uni] ; Rebecca Kelley [Royaume-Uni] ; Yvonne Silber [Royaume-Uni] ; Philip A. Beer [Royaume-Uni] ; Keefe Chng [Singapour] ; Marilyn B. Renfree [Australie] ; Kirsten Mcewen [Royaume-Uni] ; Dionne Gray [Royaume-Uni] ; Jyoti Nangalia [Royaume-Uni] ; Ghulam J. Mufti [Royaume-Uni] ; Eva Hellstrom-Lindberg [Suède] ; Jean-Jacques Kiladjian [France] ; Mary Frances Mcmullin [Royaume-Uni] ; Peter J. Campbell [Royaume-Uni] ; Anne C. Ferguson-Smith [Royaume-Uni] ; Anthony R. Green [Royaume-Uni]

Source :

The Journal of Clinical Investigation [ 0021-9738 ] ; 2013.

RBID : PMC:3635733

Abstract

Large regions of recurrent genomic loss are common in cancers; however, with a few well-characterized exceptions, how they contribute to tumor pathogenesis remains largely obscure. Here we identified primate-restricted imprinting of a gene cluster on chromosome 20 in the region commonly deleted in chronic myeloid malignancies. We showed that a single heterozygous 20q deletion consistently resulted in the complete loss of expression of the imprinted genes L3MBTL1 and SGK2, indicative of a pathogenetic role for loss of the active paternally inherited locus. Concomitant loss of both L3MBTL1 and SGK2 dysregulated erythropoiesis and megakaryopoiesis, 2 lineages commonly affected in chronic myeloid malignancies, with distinct consequences in each lineage. We demonstrated that L3MBTL1 and SGK2 collaborated in the transcriptional regulation of MYC by influencing different aspects of chromatin structure. L3MBTL1 is known to regulate nucleosomal compaction, and we here showed that SGK2 inactivated BRG1, a key ATP-dependent helicase within the SWI/SNF complex that regulates nucleosomal positioning. These results demonstrate a link between an imprinted gene cluster and malignancy, reveal a new pathogenetic mechanism associated with acquired regions of genomic loss, and underline the complex molecular and cellular consequences of “simple” cancer-associated chromosome deletions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635733

DOI: 10.1172/JCI66113
PubMed: 23543057
PubMed Central: 3635733

Affiliations:

Le document en format XML

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</affiliation>
</author>
<author><name sortKey="Edwards, Carol" sort="Edwards, Carol" uniqKey="Edwards C" first="Carol" last="Edwards">Carol Edwards</name>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cheong, Clara Yujing" sort="Cheong, Clara Yujing" uniqKey="Cheong C" first="Clara Yujing" last="Cheong">Clara Yujing Cheong</name>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Singapour</country>
<wicri:regionArea>A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine</wicri:regionArea>
<wicri:noRegion>Brenner Centre for Molecular Medicine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ito, Mitsuteru" sort="Ito, Mitsuteru" uniqKey="Ito M" first="Mitsuteru" last="Ito">Mitsuteru Ito</name>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bench, Anthony" sort="Bench, Anthony" uniqKey="Bench A" first="Anthony" last="Bench">Anthony Bench</name>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">Department of Hematology, Addenbrooke’s Hospital, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, Addenbrooke’s Hospital, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kelley, Rebecca" sort="Kelley, Rebecca" uniqKey="Kelley R" first="Rebecca" last="Kelley">Rebecca Kelley</name>
<affiliation><nlm:aff wicri:cut=" and" id="JCI66113">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute</nlm:aff>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Hematology, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silber, Yvonne" sort="Silber, Yvonne" uniqKey="Silber Y" first="Yvonne" last="Silber">Yvonne Silber</name>
<affiliation><nlm:aff wicri:cut=" and" id="JCI66113">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute</nlm:aff>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Hematology, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beer, Philip A" sort="Beer, Philip A" uniqKey="Beer P" first="Philip A." last="Beer">Philip A. Beer</name>
<affiliation><nlm:aff wicri:cut=" and" id="JCI66113">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute</nlm:aff>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Hematology, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">Department of Hematology, Addenbrooke’s Hospital, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, Addenbrooke’s Hospital, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chng, Keefe" sort="Chng, Keefe" uniqKey="Chng K" first="Keefe" last="Chng">Keefe Chng</name>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Singapore.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Singapour</country>
<wicri:regionArea>A*STAR Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine</wicri:regionArea>
<wicri:noRegion>Brenner Centre for Molecular Medicine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Renfree, Marilyn B" sort="Renfree, Marilyn B" uniqKey="Renfree M" first="Marilyn B." last="Renfree">Marilyn B. Renfree</name>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Zoology, University of Melbourne, Melbourne, Victoria, Australia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Department of Zoology, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcewen, Kirsten" sort="Mcewen, Kirsten" uniqKey="Mcewen K" first="Kirsten" last="Mcewen">Kirsten Mcewen</name>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gray, Dionne" sort="Gray, Dionne" uniqKey="Gray D" first="Dionne" last="Gray">Dionne Gray</name>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name>
<affiliation><nlm:aff wicri:cut=" and" id="JCI66113">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute</nlm:aff>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Hematology, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">Department of Hematology, Addenbrooke’s Hospital, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, Addenbrooke’s Hospital, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mufti, Ghulam J" sort="Mufti, Ghulam J" uniqKey="Mufti G" first="Ghulam J." last="Mufti">Ghulam J. Mufti</name>
<affiliation wicri:level="3"><nlm:aff id="JCI66113">Department of Hematological Medicine, King’s College London, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematological Medicine, King’s College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellstrom-Lindberg">Eva Hellstrom-Lindberg</name>
<affiliation wicri:level="3"><nlm:aff id="JCI66113">Karolinska Institute, Department of Medicine, Division of Hematology, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suède</country>
<wicri:regionArea>Karolinska Institute, Department of Medicine, Division of Hematology, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name>
<affiliation wicri:level="3"><nlm:aff id="JCI66113">Hopital Saint-Louis, AP-HP, Centre d’Investigations Cliniques, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Hopital Saint-Louis, AP-HP, Centre d’Investigations Cliniques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="JCI66113">Université Paris 7 Denis Diderot, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Université Paris 7 Denis Diderot, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmullin, Mary Frances" sort="Mcmullin, Mary Frances" uniqKey="Mcmullin M" first="Mary Frances" last="Mcmullin">Mary Frances Mcmullin</name>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">Center for Cancer Research and Cell Biology, Queen’s University, Belfast, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Center for Cancer Research and Cell Biology, Queen’s University, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J." last="Campbell">Peter J. Campbell</name>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Hematology, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">Department of Hematology, Addenbrooke’s Hospital, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, Addenbrooke’s Hospital, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferguson Smith, Anne C" sort="Ferguson Smith, Anne C" uniqKey="Ferguson Smith A" first="Anne C." last="Ferguson-Smith">Anne C. Ferguson-Smith</name>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Green, Anthony R" sort="Green, Anthony R" uniqKey="Green A" first="Anthony R." last="Green">Anthony R. Green</name>
<affiliation><nlm:aff wicri:cut=" and" id="JCI66113">Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute</nlm:aff>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="JCI66113">Department of Hematology, University of Cambridge, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="JCI66113">Department of Hematology, Addenbrooke’s Hospital, Cambridge, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Hematology, Addenbrooke’s Hospital, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Clinical Investigation</title>
<idno type="ISSN">0021-9738</idno>
<idno type="eISSN">1558-8238</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Large regions of recurrent genomic loss are common in cancers; however, with a few well-characterized exceptions, how they contribute to tumor pathogenesis remains largely obscure. Here we identified primate-restricted imprinting of a gene cluster on chromosome 20 in the region commonly deleted in chronic myeloid malignancies. We showed that a single heterozygous 20q deletion consistently resulted in the complete loss of expression of the imprinted genes <italic>L3MBTL1</italic>
 and <italic>SGK2</italic>
, indicative of a pathogenetic role for loss of the active paternally inherited locus. Concomitant loss of both <italic>L3MBTL1</italic>
 and <italic>SGK2</italic>
 dysregulated erythropoiesis and megakaryopoiesis, 2 lineages commonly affected in chronic myeloid malignancies, with distinct consequences in each lineage. We demonstrated that L3MBTL1 and SGK2 collaborated in the transcriptional regulation of <italic>MYC</italic> by influencing different aspects of chromatin structure. L3MBTL1 is known to regulate nucleosomal compaction, and we here showed that SGK2 inactivated BRG1, a key ATP-dependent helicase within the SWI/SNF complex that regulates nucleosomal positioning. These results demonstrate a link between an imprinted gene cluster and malignancy, reveal a new pathogenetic mechanism associated with acquired regions of genomic loss, and underline the complex molecular and cellular consequences of “simple” cancer-associated chromosome deletions.
</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>Suède</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Grand Londres</li>
<li>Svealand</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Cambridge</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Stockholm</li>
</settlement>
<orgName><li>Université de Cambridge</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Aziz, Athar" sort="Aziz, Athar" uniqKey="Aziz A" first="Athar" last="Aziz">Athar Aziz</name>
</region>
<name sortKey="Baxter, E Joanna" sort="Baxter, E Joanna" uniqKey="Baxter E" first="E. Joanna" last="Baxter">E. Joanna Baxter</name>
<name sortKey="Baxter, E Joanna" sort="Baxter, E Joanna" uniqKey="Baxter E" first="E. Joanna" last="Baxter">E. Joanna Baxter</name>
<name sortKey="Beer, Philip A" sort="Beer, Philip A" uniqKey="Beer P" first="Philip A." last="Beer">Philip A. Beer</name>
<name sortKey="Beer, Philip A" sort="Beer, Philip A" uniqKey="Beer P" first="Philip A." last="Beer">Philip A. Beer</name>
<name sortKey="Bench, Anthony" sort="Bench, Anthony" uniqKey="Bench A" first="Anthony" last="Bench">Anthony Bench</name>
<name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J." last="Campbell">Peter J. Campbell</name>
<name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J." last="Campbell">Peter J. Campbell</name>
<name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J." last="Campbell">Peter J. Campbell</name>
<name sortKey="Edwards, Carol" sort="Edwards, Carol" uniqKey="Edwards C" first="Carol" last="Edwards">Carol Edwards</name>
<name sortKey="Ferguson Smith, Anne C" sort="Ferguson Smith, Anne C" uniqKey="Ferguson Smith A" first="Anne C." last="Ferguson-Smith">Anne C. Ferguson-Smith</name>
<name sortKey="Gray, Dionne" sort="Gray, Dionne" uniqKey="Gray D" first="Dionne" last="Gray">Dionne Gray</name>
<name sortKey="Green, Anthony R" sort="Green, Anthony R" uniqKey="Green A" first="Anthony R." last="Green">Anthony R. Green</name>
<name sortKey="Green, Anthony R" sort="Green, Anthony R" uniqKey="Green A" first="Anthony R." last="Green">Anthony R. Green</name>
<name sortKey="Ito, Mitsuteru" sort="Ito, Mitsuteru" uniqKey="Ito M" first="Mitsuteru" last="Ito">Mitsuteru Ito</name>
<name sortKey="Kelley, Rebecca" sort="Kelley, Rebecca" uniqKey="Kelley R" first="Rebecca" last="Kelley">Rebecca Kelley</name>
<name sortKey="Mcewen, Kirsten" sort="Mcewen, Kirsten" uniqKey="Mcewen K" first="Kirsten" last="Mcewen">Kirsten Mcewen</name>
<name sortKey="Mcmullin, Mary Frances" sort="Mcmullin, Mary Frances" uniqKey="Mcmullin M" first="Mary Frances" last="Mcmullin">Mary Frances Mcmullin</name>
<name sortKey="Mufti, Ghulam J" sort="Mufti, Ghulam J" uniqKey="Mufti G" first="Ghulam J." last="Mufti">Ghulam J. Mufti</name>
<name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name>
<name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name>
<name sortKey="Silber, Yvonne" sort="Silber, Yvonne" uniqKey="Silber Y" first="Yvonne" last="Silber">Yvonne Silber</name>
</country>
<country name="Singapour"><noRegion><name sortKey="Cheong, Clara Yujing" sort="Cheong, Clara Yujing" uniqKey="Cheong C" first="Clara Yujing" last="Cheong">Clara Yujing Cheong</name>
</noRegion>
<name sortKey="Chng, Keefe" sort="Chng, Keefe" uniqKey="Chng K" first="Keefe" last="Chng">Keefe Chng</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Renfree, Marilyn B" sort="Renfree, Marilyn B" uniqKey="Renfree M" first="Marilyn B." last="Renfree">Marilyn B. Renfree</name>
</region>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellstrom-Lindberg">Eva Hellstrom-Lindberg</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name>
</region>
<name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name>
</country>
</tree>
</affiliations>
</record>

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Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions

Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions

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	Serveur d'exploration sur les relations entre la France et l'Australie
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